I haven't purchased my Zune yet. I have been reading up on some of the Zune blogs, and noticed an interesting bit on Clikzune regarding podcasts. One of the big criticisms of Zune is the "lack of podcast support." Of course, that's not correct as the Zune can play podcasts just fine. What's missing is the lack of a podcast directory on Zune Marketplace.
I listen to a lot of podcasts, a lot of which I retrieve using iTunes. Several are not DRM'd by iTunes, so my Zune software (yes, I've downloaded and installed the software without yet having a device) picks them up and can play them. I assume they will sync and play on a Zune.